Can Atherosclerosis be reversed by statins?

As a medical professional with expertise in cardiovascular health, I can provide insight into the effects of statins on atherosclerosis. Statins are a class of drugs that are widely prescribed to help lower cholesterol levels, particularly low-density lipoprotein (LDL), which is often referred to as "bad" cholesterol. High levels of LDL can contribute to the development of atherosclerosis, a condition where plaque builds up inside the arteries, potentially leading to heart attack or stroke. Statins have been shown to be effective in reducing LDL levels by up to 60%. In addition to lowering LDL, they also have the beneficial effect of raising high-density lipoprotein (HDL), which is known as the "good" cholesterol because it helps remove LDL from the bloodstream. Recent studies have indicated that long-term use of statins, for a year or more, can lead to a regression or even a slight shrinkage of the plaques that cause atherosclerosis. This discovery has been quite significant, as it was previously believed that atherosclerosis was a progressive disease that could not be reversed. However, it's important to note that while statins can slow the progression of atherosclerosis and may even lead to some reversal, they are not a cure-all. Lifestyle changes such as a healthy diet, regular exercise, and smoking cessation are also crucial components of managing and treating atherosclerosis. In summary, while statins can have a positive impact on the plaques associated with atherosclerosis, they should be used as part of a comprehensive treatment plan that includes lifestyle modifications.

Statins cause LDL levels to fall by up to 60%. They also raise levels of HDL or "good" cholesterol. ... Taking a statin for a year or longer can even slightly shrink plaques that cause atherosclerosis. This reversal of atherosclerosis surprised many experts who believed it couldn't be done.