What are the side effects of IVIG?

As a medical professional with expertise in immunology, I can provide you with information on the side effects of Intravenous Immunoglobulin (IVIG) therapy. IVIG is a blood product that contains a broad range of antibodies and is used to treat various conditions, including primary immune deficiencies, autoimmune diseases, and certain neurological disorders.

**Side effects of IVIG can be categorized into immediate and delayed:**


1. Immediate Side Effects:
- Headache: Occurs due to the rapid infusion of IVIG.
- Nausea and Vomiting: Can be a result of the body's reaction to the foreign proteins.
- Fever and Chills: Commonly associated with the immune response to the infusion.
- Flushing: May be due to the body's reaction to the infusion.
- Back Pain: Can be a result of the infusion process itself.
- Hypersensitivity Reactions: Including rash and itching, which can occur in individuals with allergies to human proteins.
- Hives: A form of skin reaction due to the immune response.


2. Delayed Side Effects:
- Thromboembolic Events: There is a risk of blood clots, particularly in patients with pre-existing risk factors.
- Aseptic Meningitis: A rare complication characterized by inflammation of the protective membranes covering the brain and spinal cord.
- Acute Kidney Injury: More common in patients with pre-existing kidney problems or those receiving high doses of IVIG.
- Increased Liver Enzymes: Sometimes the liver function may be affected.
- Weakness or Fatigue: Can occur after the treatment.

It's important to note that not all patients will experience these side effects, and the severity can vary. Patients should be monitored closely during and after the infusion to manage any potential side effects promptly.

Less serious side effects may include:mild headache;dizziness;tired feeling;back pain, muscle cramps;minor chest pain; or.flushing (warmth, redness, or tingly feeling).