Which drugs cause prolonged QT interval?
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Amelia Taylor
Studied at the University of Vienna, Lives in Vienna, Austria.
As a medical professional with expertise in pharmacology, I can provide you with a list of drugs that are known to cause a prolonged QT interval, which is a measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle. A prolonged QT interval can lead to serious heart rhythm disturbances.
Antiarrhythmic drugs are a common class of medications that can cause this effect, particularly those in class IA (like quinidine, disopyramide) and class III (like sotalol, dofetilide, and amiodarone).
Antibiotics such as macrolides (e.g., erythromycin and azithromycin), fluoroquinolones (e.g., moxifloxacin and levofloxacin), and some antifungals (like ketoconazole) are also known to prolong the QT interval.
Antidepressants and antipsychotics, including certain tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs), as well as some atypical antipsychotics, can affect the QT interval.
Antimalarial drugs like halofantrine can also cause QT prolongation.
**Certain medications for gastrointestinal disorders**, such as cisapride, which has been withdrawn in many countries due to its association with QT prolongation and serious cardiac events.
Other drugs that can cause QT prolongation include some antihistamines, antiemetics (like ondansetron), and some antihistamines (like terfenadine, which has been withdrawn from the market).
It's important to note that not all drugs in these classes will necessarily cause QT prolongation, and the risk can vary based on dosage, individual patient factors, and interactions with other medications.
Antiarrhythmic drugs are a common class of medications that can cause this effect, particularly those in class IA (like quinidine, disopyramide) and class III (like sotalol, dofetilide, and amiodarone).
Antibiotics such as macrolides (e.g., erythromycin and azithromycin), fluoroquinolones (e.g., moxifloxacin and levofloxacin), and some antifungals (like ketoconazole) are also known to prolong the QT interval.
Antidepressants and antipsychotics, including certain tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs), as well as some atypical antipsychotics, can affect the QT interval.
Antimalarial drugs like halofantrine can also cause QT prolongation.
**Certain medications for gastrointestinal disorders**, such as cisapride, which has been withdrawn in many countries due to its association with QT prolongation and serious cardiac events.
Other drugs that can cause QT prolongation include some antihistamines, antiemetics (like ondansetron), and some antihistamines (like terfenadine, which has been withdrawn from the market).
It's important to note that not all drugs in these classes will necessarily cause QT prolongation, and the risk can vary based on dosage, individual patient factors, and interactions with other medications.
Studied at University of Cambridge, Lives in Cambridge, UK
Drugs Causing QT ProlongationAntipsychotics Type IA antiarrhythmics Class III antiarrhythmics Chlorpromazine Haloperidol Droperidol Quetiapine Olanzapine Amisulpride ThioridazineQuinidine Procainamide DisopyramideSotalol Amiodarone
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Mia Thompson
QuesHub.com delivers expert answers and knowledge to you.
Drugs Causing QT ProlongationAntipsychotics Type IA antiarrhythmics Class III antiarrhythmics Chlorpromazine Haloperidol Droperidol Quetiapine Olanzapine Amisulpride ThioridazineQuinidine Procainamide DisopyramideSotalol Amiodarone
