Why does metoprolol cause weight gain?

As a healthcare professional with expertise in pharmacology, I can provide insights into the potential reasons why metoprolol might cause weight gain in some individuals. Metoprolol is a beta-blocker, a class of medications that is commonly used to treat high blood pressure, angina, and certain heart rhythm disorders. While weight gain is not a typical side effect of metoprolol, there are several mechanisms through which it could potentially contribute to weight gain: 1. Decreased Metabolism: Beta-blockers like metoprolol can slow down the heart rate and lower blood pressure, which may lead to a reduced metabolic rate. A slower metabolism can result in the body burning fewer calories at rest, which could contribute to weight gain over time. 2. Fluid Retention: Metoprolol can sometimes cause the body to retain fluids, which can lead to an increase in weight. This is more of a temporary weight gain and is not due to an increase in body fat. 3. Appetite Changes: Some individuals might experience changes in appetite while taking metoprolol. If a person starts to eat more as a result of the medication, this could lead to weight gain. 4. Reduced Physical Activity: Because metoprolol can cause fatigue or reduced exercise tolerance, some patients might become less physically active, which can contribute to weight gain. 5. Psychological Factors: The medication might also affect mood or cause depression in some individuals, which can lead to emotional eating or a reduced motivation to exercise. It's important to note that not everyone will experience weight gain while taking metoprolol, and the extent to which it occurs can vary widely. If weight gain is a concern, it's crucial to discuss this with a healthcare provider, who can offer guidance on managing weight while on the medication.

Yes. Weight gain can occur as a side effect of some beta blockers, especially the older ones, such as atenolol (Tenormin) and metoprolol (Lopressor, Toprol-XL). The average weight gain is about 2.6 pounds (about 1.2 kilograms). ... Doctors aren't sure exactly why some beta blockers cause weight gain.